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Retatrutide 30mg Retatrutide Mechanism of Action in Research Models Retatrutide functions as a balanced triple agonist, binding to GLP-1, GIP, and glucagon receptors with nanomolar affinity: GIP receptor: 0.064 nM GLP-1 receptor: 0.775 nM Glucagon receptor: 5.79 nM In research models, retatrutide activates several metabolic pathways: 1